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Comparison of propofol and fospropofol
Fospropofol Propofol Water-soluble prodrug → hydrolyzed by endothelial/hepatic alkaline phosphatases Lipid-soluble, manufactured as emulsified formulation (preservatives (like EDTA) added) Onset of action: 4-10 min 3-5 min Side Effects Paresthesias 50% 10–20% Pruritus 15–30 1–3 Respiratory depression 10 10–25 Hypotension 5 5–25 ...
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I love these videos. Why do some patients need more propofol? Propofol resistance is real—genetics, metabolism, and more can impact anesthesia dosing. #PropofolResistance #Anesthesia #Pharmacogenomics #PerioperativeMedicine #PrecisionMedicine Propofol resistance is most often due to genetic polymorphisms affecting drug metabolism and receptor sensitivity, as well as individual differences in metabolic pathways and enzyme activity. Other contributing factors include altered lipid metabolism, mito
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