Genetic variants underlying life-threatening diseases, being unlikely to be transmitted to the next generation, are gradually and selectively eliminated from the population through negative selection.
Natural selection shapes genomes to evolve and to adapt but, are the rules of natural selection also applying to cancer genome evolution? An interdisciplinary team of scientists at the Centre for ...
The fixation probability is given for heterozygous, harmful mutations. The vertical line indicates selection coefficients that satisfy Nes = 0.5 and roughly separates the domains where genetic drift ...
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